Chemical Research in Toxicology

期刊简介：Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques. Representative research includes:Studies concerning the molecular mechanisms by which physical, chemical, or biological agents or materials, interact with and perturb the normal function and/or structure of biological systems, including living organisms, cells, or biomolecules.Studies that address hypotheses concerning mechanisms of adverse or therapeutic responses, or contribute to the development of models of toxic/biological function on the basis of quantifying chemical, molecular and cellular responses to physical, chemical, or biological agents or materials.Studies involving data resulting from high content characterization of molecular responses to agents from the use of bioanalytical approaches such as proteomics, metabolomics, lipidomics, genomics, high content imaging, multi-omics, etc. to characterize targeted patterns or global cellular responses, as well as studies that use novel or existing data to create new models for quantifying exposures or building predictive models of biological pathways or networks.The identification and characterization of potentially hazardous agents such as environmental contaminants, industrial chemicals, drugs and drug-like molecules, natural products, biological toxins and engineered nanomaterials, and the development and application of novel methodologies for their detection and/or characterizations of their interactions with biological systems or biomolecules.Studies concerning pathological biochemistry and molecular mechanisms of disease etiology involving exogenous as well as endogenous agents and/or molecular pathways or networks.

【译文】化学毒理学研究发表关于毒理学各个主题的文章、快速报告、化学概要、评论、观点、编辑信件和ToxWatch，这些主题涉及化学和分子理解以及基于结构和过程的生物结果预测能力。该期刊报道的活动的主要目标是提供促进人类安全和生态系统保护所需的知识和创新方法。该期刊强调对毒性机制的洞察力，而不是现象学的观察。它坚持严格的化学、物理和数学标准，用于现代技术的表征和应用。代表性研究包括：研究物理、化学或生物剂或材料与生物系统（包括生物体、细胞或生物分子）相互作用和干扰其正常功能和/或结构的分子机制；针对不良或治疗反应的机制或基于量化物理、化学或生物剂或材料的化学、分子和细胞反应，为毒/生物功能建立模型的研究；涉及使用生物分析方法（如蛋白质组学、代谢组学、脂质组学、基因组学、高内涵成像、多组学等）进行分子反应的高内涵表征的数据研究，以及使用新颖或现有数据创建新的模型来量化暴露或建立生物途径或网络的预测模型的研究。鉴定和表征潜在有害剂（如环境污染物、工业化学品、药物和类似药物分子、天然产品、生物毒素和工程纳米材料），以及开发和应用新的方法来检测它们与生物系统或生物分子的相互作用或表征。