Drug Design Development and Therapy

期刊简介：Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications.The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validationPhenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathwaysNew methods or relevant applications in molecular/drug design and computer-aided drug discovery*Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes)Structural or molecular biological studies elucidating molecular recognition processesFragment-based drug discoveryPharmaceutical/red biotechnologyIsolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products**Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug developmentDrug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing)Preclinical development studiesTranslational animal modelsMechanisms of action and signalling pathwaysToxicologyGene therapy, cell therapy and immunotherapyPersonalized medicine and pharmacogenomicsClinical drug evaluationPatient safety and sustained use of medicines.

【译文】药物设计、开发和治疗是一本国际性的、同行评审的、开放获取的期刊，涵盖了从药物设计、发现和开发到临床应用的全过程。该期刊的特点是快速报道高质量的原研研究、综述、专家意见、评论和所有治疗领域的临床研究。期刊涵盖的具体主题包括：药物靶点鉴定和验证、表型筛选和靶点解析、药物靶点和其途径的生化分析、分子/药物设计和计算机辅助药物发现的新方法或相关应用、新型生物活性化合物的设计、合成和生物评价（包括诊断或化学探针）、阐明分子识别过程的构效或分子生物学研究、基于片段的药物发现、制药/红生物技术、天然产物的分离、结构表征、（生物）合成、生物工程和药理评价、药物或生物活性化合物在药物开发中的分布、药代动力学和代谢转化、药物递送和制剂（剂型设计、释放机制和体内测试）、临床前开发研究、转化动物模型、作用机制和信号通路、毒理学、基因治疗、细胞治疗和免疫治疗、个性化医学和药物基因组学、临床药物评价、患者安全和药物持续使用。