Frontiers in Bioengineering and Biotechnology

期刊简介：The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.

【译文】医学新发现转化为临床常规的翻译从未容易。在上个世纪的下半叶，得益于化学、生物化学和药理学的发展，我们见证了针对治疗症状、阻断不良途径以及感染性疾病中对抗微生物的药物和设备的开发与应用。然而，今天，我们面临着治疗疾病方法上的巨大变化。实际上，当前和未来十年的挑战是全面恢复患病生物体的生理状态，并在组织器官严重受损、治疗不能仅限于症状压制或损伤修复的情况下，完全再生组织器官。这一切都得益于基础细胞和分子生物学，包括干细胞科学、生长因子递送、基因分离和转染等领域的重大发展，以及生物工程和纳米技术的进步，包括新型生物材料、生物制造技术和生物反应器的应用，以及诊断工具和细胞、组织器官成像的大幅改进。在当今世界，加强多学科专家之间的沟通，以及促进科学家、工程师、行业人士、监管机构和医生之间的联合项目和紧密合作，对于任何尝试开发和应用新的生物疗法或涉及生物材料、细胞和/或生物活性分子集体使用的创新设备都是绝对必要的。“生物工程与生物技术前沿”旨在成为所有参与该过程的人的论坛，通过弥合基础科学发现与其临床应用之间过于常见的差距。