Cancer Biology & Therapy

期刊简介：Cancer, the second leading cause of death, is a heterogenous group of over 100 diseases. Cancer is characterized by disordered and deregulated cellular and stromal proliferation accompanied by reduced cell death with the ability to survive under stresses of nutrient and growth factor deprivation, hypoxia, and loss of cell-to-cell contacts. At the molecular level, cancer is a genetic disease that develops due to the accumulation of mutations over time in somatic cells. The phenotype includes genomic instability and chromosomal aneuploidy that allows for acceleration of genetic change. Malignant transformation and tumor progression of any cell requires immortalization, loss of checkpoint control, deregulation of growth, and survival. A tremendous amount has been learned about the numerous cellular and molecular genetic changes and the host-tumor interactions that accompany tumor development and progression. It is the goal of the field of Molecular Oncology to use this knowledge to understand cancer pathogenesis and drug action, as well as to develop more effective diagnostic and therapeutic strategies for cancer. This includes preventative strategies as well as approaches to treat metastases. With the availability of the human genome sequence and genomic and proteomic approaches, a wealth of tools and resources are generating even more information. The challenge will be to make biological sense out of the information, to develop appropriate models and hypotheses and to translate information for the clinicians and the benefit of their patients. Cancer Biology & Therapy aims to publish original research on the molecular basis of cancer, including articles with translational relevance to diagnosis or therapy. We will include timely reviews covering the broad scope of the journal. The journal will also publish op-ed pieces and meeting reports of interest. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The journal and the outstanding Editorial Board will strive to maintain the highest standards for excellence in all activities to generate a valuable resource.

【译文】癌症是导致死亡的第二大原因，是一组超过100种异质疾病。癌症的特点是细胞和间质增殖紊乱和不规则，伴随细胞死亡减少，能够在营养和生长因子剥夺、缺氧和细胞间接触丧失的压力下存活。在分子水平上，癌症是一种由于体细胞中随时间积累突变而发展的遗传疾病。其表型包括基因组不稳定性和染色体非整倍体，这允许遗传变化的加速。任何细胞的恶性转化和肿瘤进展都需要永生化、检查点控制丧失、生长和生存的失调。我们已经从许多细胞和分子遗传变化以及伴随肿瘤发展和进展的宿主-肿瘤相互作用中学到了很多。分子肿瘤学领域的目标是利用这些知识来理解癌症发病机制和药物作用，以及开发更有效的癌症诊断和治疗策略。这包括预防策略以及治疗转移的方法。随着人类基因组序列和基因组学及蛋白质组学方法的出现，大量的工具和资源正在产生更多信息。挑战将是使信息具有生物学意义，开发适当的模型和假设，并将信息转化为临床医生及其患者的利益。癌症生物学与治疗杂志旨在发表关于癌症分子基础的原研文章，包括与诊断或治疗相关的转化研究文章。我们将包括及时综述涵盖杂志的广泛范围。该杂志还将发表社论和感兴趣的会议报告。目标是通过对重要结果的及时发表，使用传统和电子格式促进沟通和信息的快速交流。该杂志和杰出的编委会将努力保持所有活动的最高标准，以生成有价值的资源。