Ageing Research Reviews

期刊简介：As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the aging process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.

【译文】随着人类平均寿命的延长，老龄化及其相关疾病对我们社会的影响也在增加。老龄化研究现在是成千上万个实验室的研究焦点，这些实验室包括遗传学、分子和细胞生物学、生物化学和行为学领域的领导者。老化研究评论（ARR）涵盖了这一领域的趋势。它旨在填补一个巨大的空白，即关于老龄化及其相关疾病机制的新发现的重要评论和观点的来源。对控制细胞增殖、分化和存活机制的深入了解的快速进展，正在引领我们对衰老调节的新认识。从端粒酶到干细胞，再到能量和氧自由基代谢，这是老龄化研究多学科领域的一个令人兴奋的新时代。正在确定延长寿命的操纵（如限制热量摄入）的细胞和分子基础，以及正在开发预防与年龄相关的疾病的新方法。ARR发表的文章来自广泛的衰老研究领域，侧重于衰老过程的细胞和分子机制以及如癌症、心血管疾病、糖尿病和神经退行性疾病等与年龄相关的疾病。此外，该期刊还涵盖了基础衰老研究在寿命延长和疾病预防中的应用。