Computational Biology and Chemistry

期刊简介：Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.

【译文】计算生物学与化学发表所有计算生命科学领域的原创研究论文和综述文章。特别欢迎在核酸和蛋白质序列研究、分子进化、分子遗传学（功能基因组学和蛋白质组学）、生物或化学-生物学特定建模的理论与实践、核酸和蛋白质的结构生物学等领域具有主要计算成分的高质量研究贡献。生物信息学、系统生物学、生态学、计算药理学、代谢、生物医学工程、流行病学和统计遗传学领域的高质量研究工作也将被考虑。鉴于其固有的不确定性，蛋白质建模和分子对接研究应进行彻底验证。如果没有验证的实验结果，应使用分子动力学模拟以及详细的自由能计算等作为补充技术来支持主要结论。没有额外生物见解的早期建模练习将不予考虑。综述文章通常由编辑委托，未经明确邀请不得提交给该杂志。然而，潜在作者可以发送一份简短的（一到三页）概要，编辑将对其进行评估。