Pragmatic and Observational Research

期刊简介：Pragmatic and Observational Research is an international, peer reviewed, open access journal that publishes data from studies designed to reflect more closely medical interventions in real-world clinical practice compared with classical randomized controlled trials (RCTs). Classical RCTs are designed to maximise internal validity and to establish an unequivocal cause-and-effect relationship between an intervention and an outcome. Classical RCT populations represent only minority groups of real-life patients and are thus limited in their extent. Complementary data from studies designed to reflect more closely the nature of real-world patients and medicines usage are required to inform guidelines and extrapolate research findings across the broad heterogeneous patient populations encountered in everyday clinical practice. The journal publishes data from prospective and retrospective studies designed to evaluate outcomes associated with real-world clinical practice. Dissemination of this data and the techniques and approaches used to optimise real-world modeling allows outcome validation and improved standards and collaboration in this growing area of research. The journal is characterized by the rapid reporting of reviews, original research, methodologies, analytics, modeling, clinical studies and patient surveys across all disease areas. Specific topics covered in the journal include: Pragmatic clinical trials Prospective and retrospective observational studies Quantitative and qualitative real-world research Data collection systems Comparison of non-pharmacological interventions in the real world Comparison of pharmacological interventions in the real world Comparison of pharmacological and non-pharmacological interventions in the real world Reviews of clinical databases and data capture Valid of proxy outcome measures in real-world studies Statistical approaches to patient matching in real-world studies Validation of real-world results Derivation of gold standards in real-world research Best practice and guideline reviews in real-world research Patient preference, satisfaction, convenience, acceptability and adherence Patient reported outcomes in derivation of meaningful research outcomes and study endpoints. Pragmatic and Observational Research will no longer consider meta-analyses for publication. In addition to adhering to the editorial policies specified for Dove and T&F journals, as of July 2024 the Editor-in-Chief strongly encourages the use of the following reporting guideline when submitting results of a modified Delphi consensus ACCORD (ACcurate COnsensus Reporting Document) The Editor in Chief may return your paper for revision in case you have not followed ACCORD

【译文】Pragmatic and Observational Research 是一本国际同行评审、开放获取期刊，其发布的研究数据旨在与经典随机对照试验 (RCT) 相比，更密切地反映现实临床实践中的医疗干预措施。经典随机对照试验旨在最大限度地提高内部有效性，并在干预措施和结果之间建立明确的因果关系。经典的随机对照试验人群仅代表现实生活中的少数患者群体，因此其范围有限。需要来自旨在更密切地反映现实世界患者和药物使用性质的研究的补充数据，以便为日常临床实践中遇到的广泛异质患者群体提供指导和推断研究结果。该杂志发表前瞻性和回顾性研究的数据，旨在评估与现实世界临床实践相关的结果。这些数据以及用于优化现实世界建模的技术和方法的传播可以在这个不断发展的研究领域中验证结果并改进标准和协作。该杂志的特点是快速报告所有疾病领域的评论、原创研究、方法、分析、建模、临床研究和患者调查。该杂志涵盖的具体主题包括： 实用临床试验 前瞻性和回顾性观察研究 定量和定性现实世界研究 数据收集系统 现实世界中非药物干预的比较 现实世界中药物干预的比较 现实世界中药物和非药物干预的比较 临床数据库和数据采集的审查 现实世界研究中代理结果测量的有效性 现实世界研究中患者匹配的统计方法 现实世界结果的验证现实世界研究中黄金标准的推导 现实世界研究中的最佳实践和指南审查 患者偏好、满意度、便利性、可接受性和依从性 患者报告的结果，以得出有意义的研究结果和研究终点。实用和观察研究将不再考虑发表荟萃分析。除了遵守 Dove 和 T&F 期刊指定的编辑政策外，自 2024 年 7 月起，主编强烈鼓励在提交修改后的 Delphi 共识 ACCORD（准确共识报告文档）结果时使用以下报告指南，如果您未遵循 ACCORD，主编可能会将您的论文退回进行修改