Bioorganic Chemistry

期刊简介：Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry.For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature.The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.

【译文】生物有机化学发表在分子水平上解决生物学问题的研究，使用有机化学和物理有机化学原理。该期刊的范围涵盖了有机化学-生物学界面的多个主题，包括：酶催化、生物转化和酶抑制；核酸化学；药物化学；天然产物化学、天然产物合成和天然产物生物合成；抗菌剂；脂质和肽化学；生物物理化学；生物探针；生物正交化学和仿生化学。对于涉及合成生物活性化合物的稿件，期刊要求描述的化合物的分子靶点必须已知，并且必须在稿件中通过实验证明。对于涉及天然产物的研究，如果分子靶点未知，则需要一些数据，而不仅仅是基于细胞的毒性研究，以提供对作用机制的见解。欢迎支持分子对接的研究，但必须由实验数据支持。期刊不考虑纯粹理论或计算性质的稿件。期刊发表常规文章、简报和综述。综述通常由编辑或编委会成员邀请。未经请求的综述作者应首先联系编辑或编委会成员，以确定拟议的文章是否在期刊的范围之内。