Frontiers in Molecular Neuroscience

期刊简介：Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.

【译文】《分子神经科学前沿》是一本顶级电子期刊，致力于识别关键分子及其功能与相互作用，这些分子是大脑在所有层面上结构、设计和功能的基础。我们的期刊范围包括突触和细胞蛋白、编码和非编码RNA，以及调节细胞和树突RNA翻译的分子机制。近年来，从减少系统（如神经元培养）中鉴定出大量新的细胞和突触参与者，但这些分子在活脑及其回路中的细胞和突触功能及可塑性方面的相关性尚未得到验证。使用体外工作中鉴定出的基因产物观察到的棘生长和密度效应在体内通常无法重现。我们的期刊特别关注对基因工程模型生物（秀丽隐杆线虫、果蝇、小鼠）的研究，在这些生物中，细胞和突触功能及可塑性的关键分子的改变会产生明确的结构、生理和行为变化。在老鼠身上，仅限于特定神经网络（嗅球、运动皮层、皮层层、海马子区域、小脑）的遗传改变，最好在时间和需求上得到调节，具有特殊意义，因为它们避开了潜在的补偿性发育效应。