Human Immunology

期刊简介：The journal's scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations.Research areas include:Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genesStudies of the expression, structure and function of the products of immune-related genesImmunogenetics of susceptibility to infectious and autoimmune disease, and allergyThe role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplantHistocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivityStudies of immunologic tolerance and pregnancyT cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal's scopePharmacogenomics and vaccine development in the context of immune-related genesHuman Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered.Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.

【译文】该期刊的范围包括理解区分人类个体在异体移植、妊娠、感染或疫苗的免疫反应中的遗传和功能机制，以及导致自身免疫、过敏或药物超敏反应的免疫反应。它还包括检查控制这些反应的基因在人群中的分布。研究领域包括：研究免疫相关基因的遗传学、基因组学、多态性、进化和人群分布研究；研究免疫相关基因产物的表达、结构和功能；感染和自身免疫病、过敏的易感性的免疫遗传学；免疫相关基因在造血干细胞、实体器官和血管化复合异体移植中的作用；组织相容性研究，包括同种抗体、表位定义和T细胞同种反应性研究；免疫耐受和妊娠研究；T细胞、B细胞、NK细胞和调节细胞的功能，尤其是与期刊范围相关的主题；在免疫相关基因背景下的药物基因组学和疫苗开发。人类免疫学认为免疫相关基因包括编码经典和非经典HLA、KIR、MIC、小组织相容性抗原（mHAg）、免疫球蛋白、TCR、BCR、参与抗原处理和呈递的蛋白质、补体、Fc受体、趋化因子和细胞因子。其他免疫相关基因也可能被考虑。人类免疫学还对免疫相关基因的生物信息学和影响实验室流程、器官分配、临床策略和与自身免疫和移植相关的登记的组织问题感兴趣。