Toxicology Mechanisms and Methods

期刊简介：Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy.Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including:In vivo studies with standard and alternative speciesIn vitro studies and alternative methodologiesMolecular, biochemical, and cellular techniquesPharmacokinetics and pharmacodynamicsMathematical modeling and computer programsForensic analysesRisk assessmentData collection and analysis.

【译文】《毒理学机制与方法》是一本同行评审期刊，其目标有两个。首先，该期刊包含关于外源化学物质导致毒害组织损伤机制的原研性研究。感兴趣的化学物质包括工业化合物、环境污染物、危险废物、药物、杀虫剂和化学武器。该期刊的范围从分子和细胞作用机制到在制定监管政策时考虑机制证据。其次，该期刊讨论了新方法和现有实验室方法、技术、设备的发展、验证和应用方面。讨论了各种研究方法，包括：使用标准和非标准物种的体内研究、体外研究和替代方法、分子、生化、细胞技术、药代动力学和药效学、数学建模和计算机程序、法医分析、风险评估、数据收集和分析。