Biochemical Pharmacology

期刊简介：Biochemical Pharmacology publishes original research findings, Commentaries and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics.The journal's target audience includes scientists engaged in the identification and study of the mechanisms of action of xenobiotics, biologics and drugs and in the drug discovery and development process.All areas of cellular biology and cellular, tissue/organ and whole animal pharmacology fall within the scope of the journal. Drug classes covered include anti-infectives, anti-inflammatory agents, chemotherapeutics, cardiovascular, endocrinological, immunological, metabolic, neurological and psychiatric drugs, as well as research on drug metabolism and kinetics. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review.While particular emphasis is placed on reporting the results of molecular and biochemical studies, research involving the use of tissue and animal models of human pathophysiology and toxicology is of interest to the extent that it helps define drug mechanisms of action, safety and efficacy.

【译文】生化药理学发表有关细胞和组织功能在生化及分子水平上的阐明、通过遗传、转录/翻译或药物/化合物诱导的修饰来改变细胞表型、以及外来物和药物的药效学和药代动力学的研究成果、评论和综述文章。该期刊的目标读者包括从事外来物、生物制剂和药物作用机制识别和研究的科学家，以及药物发现和开发过程中的科学家。该期刊涵盖的细胞生物学和细胞、组织/器官及整体动物药理学领域包括所有方面。涵盖的药物类别包括抗感染药、抗炎药、化疗药、心血管药、内分泌药、免疫药、代谢药、神经药和精神药，以及药物代谢和动力学的研究。虽然药物化学是一个相关的话题，但该领域的稿件必须包含足够的生物数据来描述所报道的化合物。专注于化学合成和分子建模的工作描述将不会考虑审阅。虽然特别强调报告分子和生化研究的结果，但涉及使用人类病理生理学和毒理学组织及动物模型的研究，只要它有助于定义药物的作用机制、安全性和有效性，就很有兴趣。