ACS Medicinal Chemistry Letters

期刊简介：ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)Biological characterization of new molecular entities in the context of drug discoveryComputational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistryDiscovery technologies for biologically active molecules from both synthetic and natural (plant and other) sourcesPharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and responsePharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinicMechanistic drug metabolism and regulation of metabolic enzyme gene expressionChemistry patents relevant to the medicinal chemistry field

【译文】ACS 医药化学通讯杂志感兴趣接收讨论医药化学各个方面的稿件。该杂志将发表涉及广泛主题的研究，包括化合物设计和优化、生物评价、药物递送、成像剂以及小分子和大分子生物活性分子的药理学。具体领域包括但不限于：先导生物活性分子和药物（小分子和生物制剂）的鉴定、合成和优化，药物发现中新分子实体的生物表征，用于生物活性分子、配体及其靶点的识别或SAR分析的计算机、化学信息学和结构研究，包括辐射生物化学在内的新颖和改进的方法，这些方法在医药化学中有广泛应用，从合成和天然（植物和其他）来源的生物活性分子的发现技术，解决药物处置和反应机制的药代动力学/药效学研究，用于增强药物设计和将医药化学转化为临床应用的药代遗传学和药基因组学研究，药物代谢的机制和代谢酶基因表达的调节，与医药化学领域相关的化学专利