Cellular and Molecular Bioengineering

期刊简介：The field of cellular and molecular bioengineering seeks to understand, so that we may ultimately control, the mechanical, chemical, and electrical processes of the cell. A key challenge in improving human health is to understand how cellular behavior arises from molecular-level interactions. CMBE, an official journal of the Biomedical Engineering Society, publishes original research and review papers in the following seven general areas:Molecular: DNA-protein/RNA-protein interactions, protein folding and function, protein-protein and receptor-ligand interactions, lipids, polysaccharides, molecular motors, and the biophysics of macromolecules that function as therapeutics or engineered matrices, for example.Cellular: Studies of how cells sense physicochemical events surrounding and within cells, and how cells transduce these events into biological responses. Specific cell processes of interest include cell growth, differentiation, migration, signal transduction, protein secretion and transport, gene expression and regulation, and cell-matrix interactions.Mechanobiology: The mechanical properties of cells and biomolecules, cellular/molecular force generation and adhesion, the response of cells to their mechanical microenvironment, and mechanotransduction in response to various physical forces such as fluid shear stress.Nanomedicine: The engineering of nanoparticles for advanced drug delivery and molecular imaging applications, with particular focus on the interaction of such particles with living cells. Also, the application of nanostructured materials to control the behavior of cells and biomolecules.

【译文】细胞与分子生物工程领域旨在理解细胞在机械、化学和电学过程中的机制，以便我们最终能够控制这些过程。改善人类健康的关键挑战在于理解细胞行为如何从分子层面的相互作用中产生。CMBE是生物医学工程学会的官方期刊，发表以下七个领域的原创研究和综述论文：分子学：DNA-蛋白/RNA-蛋白相互作用、蛋白折叠和功能、蛋白-蛋白和受体-配体相互作用、脂质、多糖、分子马达以及作为治疗剂或工程基质的生物大分子的生物物理学。细胞学：研究细胞如何感知细胞周围和内部的物理化学事件，以及细胞如何将这些事件转化为生物反应。感兴趣的特定细胞过程包括细胞生长、分化、迁移、信号转导、蛋白分泌和运输、基因表达和调控以及细胞-基质相互作用。机械生物学：细胞和生物分子的机械特性、细胞/分子力生成和粘附、细胞对其机械微环境的反应以及响应各种物理力（如流体剪切应力）的机械转导。纳米医学：纳米颗粒的工程化用于先进的药物递送和分子成像应用，特别关注这些颗粒与活细胞的相互作用。此外，纳米结构材料的应用用于控制细胞和生物分子的行为。