Cell chemical biology

期刊简介：Cell Chemical Biology is a Cell Press journal publishing research and review content of exceptional interest for the chemical biology community. Launched in 1994 under the title Chemistry & Biology, the journal was the first to recognize the growing importance of investigations done at the interface of chemistry and biology, and its mission has always been to support and promote chemical biology and conversation and collaboration between chemical and life sciences.Cell Chemical Biology strongly encourages submission of articles that provide significant conceptual advancement of broad general interest to both chemists and biologists. We are especially interested in papers that combine the use of chemical tools to perturb, visualize, and measure biological systems and properties and offer unique insights into molecular mechanism or physiology. We also encourage submissions that are focused on method development for basic life sciences or that have practical impact of either clinical or biotechnological nature. Some additional types of research that we consider within our scope are studies of metabolism and physiology; enzyme mechanism and natural product biosynthesis; generation, distribution, and function of small molecule-protein conjugates such as post-translational modifications; mechanism of resistance to small molecules by viruses/bacteria/cancer cells/organisms; intra- and intercellular and intra- and interspecies communication mediated by small molecules; and chemical biology of lipids, sugars, and nucleic acids. Finally, large-scale studies enabled by the use of chemistry-based technology, such as proteomics, lipidomics, metabolomics, and glycomics, are also within our scope, as well as synthetic and systems biology work when inspired and supported by chemical tools or aimed at engineering biological systems to perform a new type of chemical transformation.

【译文】Cell化学生物学是一本Cell Press出版社出版的期刊，发表对化学生物学领域具有非凡兴趣的研究和评论内容。该期刊于1994年以《化学与生物学》的名称启动，是第一个认识到化学与生物学交叉研究日益重要性的期刊，其使命始终是支持和促进化学生物学以及化学与生命科学之间的对话与合作。Cell化学生物学强烈鼓励提交那些对化学家和生物学家都具有广泛一般性兴趣的概念性重大进展的文章。我们特别感兴趣的是结合使用化学工具来干扰、可视化和测量生物系统和特性，并为分子机制或生理学提供独特见解的论文。我们还鼓励提交专注于基础生命科学方法开发或具有临床或生物技术性质的实际影响的论文。我们还考虑在我们范围内的一些其他类型的研究，包括代谢和生理学研究；酶机制和天然产物生物合成；小分子-蛋白质共轭物（如翻译后修饰）的生成、分布和功能；病毒/细菌/癌细胞/生物体对小分子的耐药机制；由小分子介导的细胞内和细胞间以及物种间通信；以及脂质、糖和核酸的化学生物学。最后，通过使用基于化学技术的技术（如蛋白质组学、脂质组学、代谢组学和糖组学）进行的大规模研究也属于我们的范围，以及受化学工具启发并由化学工具支持或旨在将生物系统工程化为执行新型化学转化的系统生物学工作。