Xenobiotica

期刊简介：Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology

【译文】Xenobiotica 期刊涵盖了七个主要领域，包括：一般异生物化学，包括体外研究，涉及药物和其他异生物的代谢、处置和排泄，以及相关酶的结构、功能和调节；临床药代动力学和代谢，涵盖药物和其他异生物在人体内的药代动力学、吸收、分布、代谢和排泄；动物药代动力学和代谢，涵盖药物和其他异生物在动物体内的药代动力学、吸收、分布、代谢和排泄；药代遗传学，定义为识别和功能表征编码异生物代谢酶和转运蛋白的多态性基因，这些基因可能导致对异生物的酶促、细胞和临床反应改变；分子毒理学，涉及毒性机制和异生物分子水平毒理学的研究；异生物转运蛋白，涉及所有涉及异生物在细胞内外移动的载体蛋白方面，以及它们对动物和人体药代动力学行为的影响；异生物化学专题，以综述和评论的形式，主要旨在对问题进行批判性分析，其中作者就数据的相关性或特定的实验方法或技术提出意见。