Journal of Cachexia Sarcopenia and Muscle

期刊简介：The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials that are related to cachexia and sarcopenia, as well as to body composition and its physiological and pathophysiological changes during the lifespan and in response to different illnesses from all fields of the life sciences.The term cachexia describes involuntary weight loss that is observed in the course of many chronic diseases, and is one of the most debilitating and life-threatening aspects of various illnesses at advanced stages. Cachexia, wasting syndromes and sarcopenia are becoming a concerning challenge for an increasing number of patients, their relatives and the medical teams caring for them. The Journal of Cachexia, Sarcopenia and Muscle aims to offer a reliable resource to all professionals who are interested in related research or who are involved in the clinical care of affected patients, for example those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.Alterations in body composition, particularly those affecting skeletal muscle, are key elements in the ageing process and in the pathophysiology of several chronic illnesses. Sarcopenia, i.e. loss of functional muscle mass without weight loss, is part of the ageing process and may play a role in reduced physical performance, falls, and disability. Studies on the functional importance of fat tissue and mechanisms leading to lipolysis are equally of interest as are studies on mechanisms of muscle wasting.The pathophysiology of cachexia involves a complex interaction between disease and body. Consequently, numerous potential therapeutic approaches are being considered and developed. Diagnostic and assessment approaches also involve researchers and clinicians seeking better screening and evaluation options and enhanced biomarkers through validated complementary investigations. This makes the Journal of Cachexia, Sarcopenia and Muscle a reliable resource of information for physicians, biochemists, biologists, dieticians, pharmacologists, and students dealing with cachexia, wasting and sarcopenia in various diseases.

【译文】《消瘦、肌肉减少症与肌肉杂志》是一本同行评审的国际期刊，致力于发表与消瘦、肌肉减少症以及身体成分及其在生命过程中以及应对不同疾病时的生理和病理生理变化相关的材料。消瘦一词描述了在许多慢性疾病过程中观察到的非自愿性体重减轻，是各种疾病晚期最致残和最具生命威胁的方面之一。消瘦、消耗综合征和肌肉减少症正成为越来越多的患者、他们的亲属以及照顾他们的医疗团队面临的令人担忧的挑战。该杂志旨在为所有对相关研究感兴趣或参与受影响患者临床护理的专业人士提供可靠的资源，例如那些患有艾滋病、癌症、慢性心力衰竭、慢性肺病、肝硬化、慢性肾功能衰竭、类风湿性关节炎或败血症的患者。身体成分的改变，尤其是影响骨骼肌的改变，是衰老过程和几种慢性疾病的病理生理学中的关键要素。肌肉减少症，即无体重减轻的功能性肌肉量减少，是衰老过程的一部分，可能在降低体能、跌倒和残疾中发挥作用。对脂肪组织功能的重要性以及导致脂肪分解的机制的研究同样有趣，对肌肉消耗的机制的研究也很有趣。消瘦的病理生理学涉及疾病与身体之间的复杂相互作用。因此，正在考虑和开发多种潜在的治疗方法。诊断和评估方法也涉及研究人员和临床医生寻求更好的筛查和评估选项以及通过验证的补充调查来增强生物标志物。这使得《消瘦、肌肉减少症与肌肉杂志》成为处理各种疾病中消瘦、消耗和肌肉减少症的医生、生物化学家、生物学家、营养师、药理学家和学生的可靠信息资源。