Toxicology in Vitro

期刊简介：Toxicology in Vitro publishes original research papers and reviews on the application and use of in vitro systems for assessing or predicting the toxic effects of chemicals and elucidating their mechanisms of action. These in vitro techniques include utilizing cell or tissue cultures, isolated cells, tissue slices, subcellular fractions, transgenic cell cultures, and cells from transgenic organisms, as well as in silico modelling. The Journal will focus on investigations that involve the development and validation of new in vitro methods, e.g. for prediction of toxic effects based on traditional and in silico modelling; on the use of methods in high-throughput toxicology and pharmacology; elucidation of mechanisms of toxic action; the application of genomics, transcriptomics and proteomics in toxicology, as well as on comparative studies that characterise the relationship between in vitro and in vivo findings. The Journal strongly encourages the submission of manuscripts that focus on the development of in vitro methods, their practical applications and regulatory use (e.g. in the areas of food components cosmetics, pharmaceuticals, pesticides, and industrial chemicals). Toxicology in Vitro discourages papers that record reporting on toxicological effects from materials, such as plant extracts or herbal medicines, that have not been chemically characterized.

【译文】《体外毒理学》发表关于利用体外系统评估或预测化学物质的毒性效应及其作用机制的研究论文和综述。这些体外技术包括使用细胞或组织培养、分离的细胞、组织切片、亚细胞组分、转基因细胞培养以及转基因生物的细胞，以及计算机模拟。该期刊将重点关注涉及开发和新方法验证的研究，例如基于传统和计算机模拟预测毒性效应的方法；在高通量毒理学和药理学中使用方法；阐明毒性作用机制；基因组学、转录组学和蛋白质组学在毒理学中的应用，以及描述体外和体内发现之间关系的比较研究。该期刊强烈鼓励提交专注于体外方法开发、其实际应用和监管用途（例如在食品成分、化妆品、药品、杀虫剂和工业化学品等领域）的稿件。体外毒理学不鼓励报道未经化学特征描述的植物提取物或草药等物质的毒理学效应的论文。